PhD Theses and Dissertations
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Item Cement Raw Mix Designing, Clinkerization Additiion of Waste Baggase From Sugar Industries and Its Impact on Fuel Consumption and Clinker Potential(INSTITUTE OF CHEMICAL SCIf,NCES, 2005) Noor ul Amin; Supervisor By: DR. KIIURSHID ALIllu&! kr /\lmigltty Alldh, lhc tr 61 h@iful, rh. mct Fwrful. wh@ 6dl* bl6i!g! Itidcd .!d ltagtt i.d rc h tL .e@Plidtlstt of lhi! ltsk .!d .Dblcd @ to brilg it i! a FwaL!|. fom I aFa th.d.r.rd Pdyd toD lb! d.9lh ofEy ba.t b rot 6wiL' oo.t &.p.ctrbL, Li.d .!d w.ll la.D.d ,p.rvi!d D!. Kh'3hid Ali Attocira Prefds' I$dtua. of Ch@iel Sci.oc.r, Uoiv6titv of Pdh!$nr, for !i3 u*Ad $886lioE1 td iEt ftrt ir ny md(, tilca! alo.ng.d.d, iDsPind8 diod! ad dirnuldi,g di!c{!sio! ihouglod Oi! {otl( It givd m. gn ! pL'lw to cxptl'3 mv d..p scosc of grditud. .rd tartr lt ltlak to ry co_sPqvilor Pmf D!. MultbDld T.!it Sb!, N&odrl Coto of Ero.IdE i! O@loE/' UliEnV of P!.ltw for hi! rrdro. .oop.dio!, v.lulbt sgS.niolr, t @ ilt fttt !!d Povidin8 ftll h.ilitieg i! !b bboddy duinS lh. @lr ofnt esr. With d.Gp 3.6!. of gtliti. ald lppr.cittioo I wuld lik lo cdod dv lp@irl rh.dr io r"r. z.tu lqb.! lrdrg.r Qudig Coltol, Cb6tt C@.ot C@Puv Linir.d No*&..t, fd hi, vd@blc augsBtid!' 3iE@ st@lEsc|Mr r"d Stat coopcblioo in nY cafth $ro*. I .n alto tEy drcl lboldi l,o Dr. H..bib_rR.hm!! &d Dr' F32lu['! Klln B&8rsL llnitul. of Cl@icd S.i6ccs, Uliv.'sitv of P€hlw for Fir .|1.o@8i!g ltritud. duilg th. col$ of lry tudv TbDb to Mr. Li!4at Ali Rd.!t h A!si!t! Ndiold Ctot.t of Exelb@ in C@log, Univ6ily of P€I.s for h! SMI lElg .!d @pdtion duin8 ov spditrEt l m* ed ny PhD @llcasw Anveul-Hlc Ali Shlh fd hit uforEen blc cooF doo duilg rhc @ur. of dv Eat h rdlcItem Characterization and Regeneration fo Carbonaceous Substrate Produced from Biotic Precursors and its Use for the Waste Water Treatment(INSTITUTE OF CIIEMICAL SCIENCES, 2006) Sultan Alam; Superversor By: DT. FAZLULLAq KTIAN BANGASITAll praiscs ro Alnigbry Allai, who guidcs us ih darkn.s ro light and blssing the Holy Prcphct Muhd.fd (!ace be lpon him) who 6ableItem Development of New Methods for Determination and Identification of Pesticides in Real Sample(INSTITUTE OF CHEMICAL SCIENCES, 2006) Nadia Bashir; Supervisor By: Dr. M. Rasul JanAt tfr. ptuire Jd aetithq Atrfr tulb .tu6Qt ant .@wdset tu ta conptev tnn w4 t{. 6^ t5. Fnwars. oJ EsM drt lnirtun dat.guiN fiis hunst tude witi Mtztfei6tt I fett@t pt@ anf tdai.tqreiit B! ri@ gtutitutr tr "tt s,q.tunot, a,tf arqsrlt 1b fu ra nt!45t gtid4u., @B?tut f.b ,rd tuomgMt thtuusfr.tt tEL' eo& I wit ae$y tuk stutdtt to En f6 tfi. 6ht 6. 8@i@tj tantz{@ tr Mci qoa li' pnciow tin. r{t.aanot.UB tt tu.@ ant.4dt of ry d'ep.n dry.ciatioaJu nJ .o. 'LVtuidat Jsnin JfiaE n eB trt., wfio w a{ery thtu ia th. Sour af n rt, t wnt to tfiefu rdfu rd ftnl i.frdeba Mtad,b dtwc6, tituE fltsatia$ dnt co86tu tu6! ttut dlltiia I @ttf, 6fu tb.rytus ntt rqftcbtian to nr prdL' fu 6rn tu., ptuy ant ltuntuI ippofl spudl6d& to ry 6tu{rn rtu{ N16 fu tt i Iandtr dat s"Pdti"g attihtd. dsins 8t 'a64Item Malondialdehyde A Marker of Oxidative Stress in Diabetes Mellitus With and Without Coronary Heart Disease(INSTITUTE OF CHEMICAL SCIENCES,, 2006) Muhammad Ahmad; Supervisor By: Dr. abdus Sattar KhanWith g@r pl.durc I dp6s my gtldrudc to Dr. A- S.d'r Khaq M.S.. Ph.D., PFfc$. of BimrEnist y, Koh.t Univdity of S.i.M sd Tdhnolo&', Koha! stlo prcvid.d srcat inantirc, crcomg.ncnt and guidmc. I m ako g6r.irl to Dr, HaMn u R4hid, M.sc. Ph,D,, ?rcf.st ed Ch!iE!4 D.parthcnt ofchmkry. Unjvdity oft.shlwr, for hi! h.tp old cuid&c. thdu8hour ihis Es.arh, I u dso g6Gtul ro Dr. Mudrsir AlDrd ru.4 M.B.B_S., M.phil.. !h.D., tueciarc Prof€sr Dcpgrr!.nr of Bi@h.nist y, Khybcr Medical Collcgd, tahw, who id spir. of bcitrs vdy buy s g@ioB GnouSh &. his gujd@, 4@ugdat dd uEDn hclp dwirS wiou .r!g6 of lhc $carch poj.ct,nd the dcElopmqr ofilis th6is, M6y rhd.b ro Dr. ZlrtuNl.h, rnch&g., !MRC, Rcsadh ccdr.., Kihybd Medi@l Coltcge, p.shawr. for prcvidins n @sery Ebonrory fa.ilitiB 0F!g[our Ojs Esrcl pDje1Item 18_Enrichment of Vegetables with Trace Minerals that may Potentially Act as Hypoglycemic Agents in the Treatment of Diabetes(INSTITUTE OF CHEMICAL SCIENCES, 2007) Javed Abbas Bangash; Supervisor By: Dr. Abdus Sattar KhanFi6t trd foftriolt I wjlh to a(9t s! hv h.arl'f6lt !&ritsd€ to w Suodiso.. Dr A. sane f.h!, M.Sc PhD, Profsr of Bio.h@aiv' 9r66nlv Koid Utuvsrty of S.i@ di l4ltuloljr. Kohdl who h&s t a nt Cr€rd poD rhr6u'rDu( Hb Dor6'ml shlls ud fruirarl ru|tg6lom rud. rhi! work ! lol G'd aor n; I m d;ry oblr.d to hin lor hit s'ld€ supFkioq Lrd M.viou dpcd cu'd@ {d cqBr@r s6i!E .t tll 86 of lhB @rd' poj6l I d .t$ grd.nt lo Dr llc@l J.4 Pbfe. ed Dicto. lnnituG of chenicd sciac6, Uriv6ity of Pdh.w.r, for his h.lp dd a[ pdiblc aidte throudolt lnb |66ch I d eqully StxLful ro En& Mohsm.d Taiq @iEdor Casd) P*ison coucil or s;6ailic dd hdusldtl R.sdch codplc\ Pdh.we, for his ldrd @{pera!@ dd pl&irg a! my dBposablo dl th. h4ilitis tquild lo cohDlote I arso fike to 6ck owledS€ mv MioB ofPakisl$ couol ofsciqlific a.d Indutnal R4eircn Conpla, P.sb.w; Mt Mohmmd RrI Kh& (Sdior Sddlfic Oiis)pfiid tFhdge Food &d Nurilioh Sddon of Fo.d t{'lmloSv C.e, ld his help dd cFp€sdon 0uouehod th. @rl Mr' Fsidull.h Knm rs@'o; Scidufrc txn@). to; uuluna his 6pcni!. dons lralvts o' Arohic i\bsrDrid sp6Lospy, sd Mr. Mutr{d Kiu Ondpd so !fic Oms) IF chorse E rimnrd nl Sdim.for tdp duins Ml.r tulrvssItem Determination of Various Sulfur Compounds in Indigenous Crude Oils and The Development of Biochemical Desulfurization Techniques(INSTITUTE OF CHEMICAL SCIENCES, 2008) Mohammad Naeem; Supervisor By: DR. MOHAMMAD ISHAQWith the name of almighty Allah, I feel great honor and privilege to record my deep sense of gratitude to my learned and kind hearted supervisor, Dr. Mohammad Ishaq, Associate professor, Institute of Chemical Sciences, University of Peshawar for his valuable guidance, inspiring and ever encouraging attitude throughout this research work. I extend my gratitude to Dr. Imtiaz Ahamad, Assistant professor, Institute Of Chemical Sciences, University of Peshawar for his wonder full support and positive criticism, who make me able to complete this research work. I am much thankful to Prof. Dr. M. Rasool Jan, Director Institute of Chemical Sciences, University of Peshawar for providing all the research facilities during this work. I am obliged to Dr. M. Shakirullah, Dr. Habib-u-Rahaman and Dr. Yousaf Iqbal for their encouragement and positive suggestions. I am grateful to DR. Murad, Dr. Iqbal, Mr. Nazeer khan, Mr. Thamur Ahmad, Mr. Mehtab Faisal, senior scientific officers (SSO), PCSIR laboratories, Peshawar, especially microbiology section for providing all the available research facilities during this work.Item Functionalization and Heteroannulation of Quinazolone Nucleus-Synthesis, Structure Elucidation and Bioactivity Evaluation(INSTITUTE OF CHEMICAL SCIENCES, 2008) RASOOL KHAN; Supervisor By: Dr. Mohammad ArfanThe research work documented in this dissertation presents the synthesis and bioactivity evaluation of some quinazolin-4(3.H)-one based heterocyclic compounds. Part first is concerned with the synthesis and synthetic methods both reported and newly designed and developed, while the second part is about the bioassays evaluation of the synthesized quinazolin-4(3H)-ones. 2-Aryl -4H-3,1-benzoxazin-4-one and methyl-Nacylanthranilates were prepared as starting materials for further transformations into a series of various 2,3-disubstituted quinazolin-4(3H)-ones. Keeping in view the extensive applications of 2-aryl -4H-3,1-benzoxazin-4-one as precursor in the quinazolin-4(3H)-ones chemistry, a new, cheaper andfacile one-pot method for the synthesis of 2-aryl -4H-3,1-benzoxazin-4-one was developed making use of readily available substituted benzoic acids. A faster and high- yielding microwaveassisted, solvent free method was also developed for the synthesis of methyl-2- [(trifluoroacetyl) amino] benzoate. Both the 2-aryl -4H-3,1-benzoxazin-4-one and methyl-N-acylanthranilates synthesized were then utilized for the synthesis of 3-amino, 2-alkyl/aryl quinazolin- 4(3H)-ones and 2,3-disubstituted quinazolin-4(3H)-ones. Consequently, a series of fifteen (19-33) 3-amino- 2-alkyl/aryl substituted quinazolin-4(3H)-ones anda series of twenty seven (46-62) 2,3-disubstituted quinazolin-4(3 H)-ones were synthesized. The necessity of development of new, cheaper and faster methods was realised and as a result, a simpler and less tedious three component one-pot method for the synthesis of ten ( 22-31) 3-amino, 2-aryl quinazolin-4(3H)-ones was developed starting from the available substituted benzoic acid. As a consequenceof the effect of substituents on the reactivity of 2-aryl -4H-3,1- benzoxazin-4-ones, three structurally novel quinazolin-4(3H)-ones (34-36) were synthesized from substituted 2-phenyl-4H-3,1-benzoxazin-4-ones. It was found that phenyl group substituted at position 2 failed to give any product. Reasons for the observed effect onthe reactivity are proposed. Keepingin view the importance of the nature and position of substituents in drug discovery, a series of (37-62) 2, 3-disubstituted quinazolin-4(3H)-ones were synthesized employing three different methods. The effect of substituents on the reactivity and theItem Bioactive Constituents from Mallotus Philipensis and Litsea Monopetala, Synthesis of O-Alkylated Bergenins and Evaluation of Their Biological Activities(INSTITUTE OF CHEMICAL SCIENCES, 2009) Hazrat Amin; Supervisor By: Dr. MohammadArfanFirst ofall I bow my headto the Omniscient, Omnipotent and Omnipresent ALMIGHTY ALLAHwho showered upon meall His blessings throughout my efforts for the completion of this research work. + It gives me a pleasant feeling to acknowledge my inimitable, fabulous and treasured research supervisor Prof. Dr. MohammadArfan, Director of the Institute of Chemical Sciences, University of Peshawar for his keen and continuous interest, valuable guidance and untiring efforts throughout this assignment. His guidance and knowledge that he has bestowed on meis an unending source of inspiration, not only for this study but also will enlighten my ways in the days to come. ¢ I wish to express my heartiest gratitude to our research collaborator Dr. Ryszard Amarowicz, Division of Food Science Institute of Animal Reproduction and Food Research of Polish Academy of Sciences Olsztyn, Poland, who helped me during my doctoral research work. > I deeply owe thanks to Dr. Muhammad Raza Shah and Prof. Dr.Vigqar Uddin Ahmad, HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi for facilitation during mystayas collaborative rescarch scholar in their res arch laboratories at the HEJ researchinstitute of chemistry, University of Karachi.Item 19_Evaluation of Antibacterial, Antifungal, Antioxidant Activities and Phytochemistry fo Selected Species Belonging to Families Pinaceae, Solanaceae and Guttiferae(INSTITUTE OF CHEMICAL SCIENCES, 2009) Mumtaz Ali; Supervisor By: Dr. Mohammad ArfanAll praises to Almighty Allah, the creator of universe Who created human beings as the best of the creatures. Many thanks to Him, who blessed us with knowledge to differentiate between right and wrong. Many thanks to Him as He blessed us with the Holy Prophet Hazrat Muhammad (Peace be upon Him) for Whom the whole universe was created. The Prophet (Peace be upon Him) enabled us to worship only one Allah. He (PBUH) brought us out of darkness and enlightened the ways to the Heaven. I feel great pleasure in expressing my ineffable thanks to my ever encouraging, inspirational, cool minded and learned supervisor Prof.Dr. Mohammad Arfan (Director, Institute of Chemical Science), whose personal interest, thought provoking guidance, valuable suggestions and discussions enabled me to complete this tedious work. He really encouraged me in all my attempts during this research work. Deep senses of gratitude and heartfelt thanks are owed to Dr. Raza Shah (HEJRIC University of Karachi) and Dr. Derek (University of Bradford UK) for their thoughts provoking discussions, valuable suggestions and their assistance in spectral and biological studies throughout my research in their research laboratories. I am thankful to Prof.Dr. Rasool Jan (Ex-Director, Institute of Chemical Science) in facilitating my research by taking bold steps for the proper utilization of indigenous fellowship funds. Thanks to all the faculty members, especially to all teachers of organic chemistry section for their morale boosting and encouraging behavior. I am highly indebted to the HEC Pakistan, for financial support through its Indigenous PhD Scheme and also for sponsoring my research visit to University of Bradford UK under the commendable scheme (IRSIP).Item Phytochemical and Biological Investigation of Some Species of Family Leguminosae(INSTITUTE OF CHEMICAL SCIENCES, 2009) Khair Zaman; Supervisor By: Dr. M. Rafiullah KhanAt the very outset of my acknowledgementI would like to thankAllah for blessing me with good health and intellect to accomplish this work. It is only His blessings which enabled me to reachthis apex level of knowledge in the field of Chemistry. This workis a synergistic product of many minds. I am grateful for the inspiration, knowledge and wisdom of all the thinkers who enabled me to put pen to paper, among them are my parents, all myrespectedteachers, students and friends who deserve first mention in this dissertation. A deepsense of gratitude andindebtedness is extendedto ever alfectionate Prof. Dr. M. Rafiullah Khan for his sincere cooperation and encouragement. Many people and forces contrihuted significantly to the completion of this study. They all deserve my deepest gratitude for providing me the opportunity and conditions to complete this thesis. | wish to thank a numberof people who influenced and supported me directly or indirectly in completing this dissertation. Perhaps words are too shallow to express mygratitude to mysupervisor Prof, Dr. Rafiullah Khan. Without his academic guidance, enthusiastic support, scholarly advice and critical feedback, it would not have been possible for me to accomplish this scholastic task. | must pay him a warmtribute for his kind behaviour, valuable advice, constructive criticism, timely suggestions, hourlong discussions and constant encouragement all the time.Item 27_Lipid Metabolism Study in Women of Pregnancy Induced Hypertension Cases(INSTITUTE OF CHEMICAL SCIENCES, 2010) Rubina Nazli; Supervisor By: Prof. Dr Muhammad Rasul JanAll acclamations and appreciation’s are for all mighty Allah, who bestowed mankind with knowledge and wisdom. Allah has the knowledge of known and unknown and equipped his humble creature with mental facility to search for his creation. This is his mercy and grace that enabled me to complete this work. I feel great pleasure and honor in expressing my sincere gratitude to my supervisor, Prof. Muhammad Rasul Jan, Ex Director, Institute of Chemical Sciences University of Peshawar and present Vice Chancellor of Malakand University, for his valuable guidance, constant help and encouragement throughout this work. I want to thanks Prof. Dr.Jasmin shah, Institute of Chemical Sciences University of Peshawar for her kind behavior, valuable advices, timely suggestions and constant encouragements all time.Item Assessment of Selected Toxic Heavy Metals in Industrial Effluents and Drinking Water and Their Effects on the Vegetation and Nutritional Status of Peshawar(INSTITUTE OF CHEMICAL SCIENCES, 2011) Fazal Akbar Jan; Supervisor By: Prof. Dr. Muhammad IshaqI consider it my supreme duty to offer my humble submission before Almighty Allah Who enabled me to complete this work. I feel great delight and happiness in expressing heart felt gratitude to my research supervisor, Prof. Dr. Muhammad Ishaq Mohmand, Institute of Chemical Sciences, University of Peshawar for his motivating and stirring guidance, devotion of time, valuable suggestions and courteous behavior in completing this work. I am fortunate enough to get kind Guidance in my research from my cosupervisors Dr. Ihsanullah Deputy Chief Scientist Nuclear institute for Food and Agriculture NIFA Peshawar and Dr. Sardar Khan Associate Professor Department of Environmental Sciences, University of Peshawar whose dignified attitude with highly specialized guidance, skilled advice, encouragement and wisdom made the completion of this work possible. I also express my warm and deepest gratefulness to Prof. Dr. Imdadullah Director and Prof. Dr. M. Rasul Jan, and Prof. Dr. Muhammad Arfan ex- Directors, Institute of Chemical Sciences, University of Peshawar, for their kind cooperation and placing at my disposal all the required facilities, to complete this work. I also express my warm and deepest gratefulness to Dr. Syed Muahmmad Asim Department of Statistics University of Peshawar and Dr. Aurangzed deputy Chief Scientist Nuclear institute for Food and Agriculture NIFA Peshawar for their kind cooperation and advice when I needed. I am also grateful to Prof. Dr. M. Shakirullah and Dr. Imtiaz Ahmad, Associate Professor, Institute of Chemical Sciences, University of Peshawar, for their co-operation, inspirational guidance and timely assistance. Very many thanks to Higher Education Commission of Pakistan for funding my PhD studies and six month visit to UK under IRSIP. I am also grateful to Mr. Mohammad Ismail, Mr.Janullah Ph.D Scholars for their assistance and help, back up and discussion through out my research work and in solving my academic problems which I faced during my Ph.D studies. Similarly I would like to show appreciation to my friends; Noor Zada, Hussain Gulab, Attaul Haq, Fazal Wahid, Zafar Iqbal and all my other M.Phil and Ph.D colleagues for their jovial company. I am also grateful to Lab. Assistants Rehman-u-din, Sabaz Ali khan Institute of Chemical Sciences, University of Peshawar for their co-operation in providing me the lab accessories, chemicals etc. I would like to pay thanks to the kind Librarian Mr. Aziz-ur-Rehman Institute of Chemical Sciences University of Peshawar, whose timely co-operation enabled me to fulfill my literature survey etc. on time. Last but not the least I would like to thank my parents who helped me in every possible way during this research work, and bear my absence from the home, adorn me with their consistent DuItem Assay of Locally Used Herbicides using Derivatization, Comlexation and Flow Injection Spectrophotometric Methods(INSTITUTE OF CHEMICAL SCIENCES, 2011) Mian Muhammad; Supervisor By: Prof. Dr. Muhammad Rasul Janl^ the ^avAe of Allah, tl^e Most Qracious, the Most Merciful. All Praise and thanks be to Allah, the Rabb (Onlg God, Cherisher a^d gustai^er) ol the Worlds, for all the blessings that He l^as give^ r"te, especiallg in guid.ing vae to tslaua since birth. Mag the peace and blessings of Allal\ be upa^ aur Prophet, Muhaunad (9allallaho alaihe wasallara), and upon his larailg and his covnpanions, and whoever follows his 9unnah till the Dag of Judgnent. ln the first place t aM deeplg indebted. ta w\g teacher and mg supewisor, Prof, Dr. Muhanynad Rasul Ja^ wl".ose ca^sta^t guidance & e^caurageqe^t gave Me the rmoral and Me^tal support which I needed. in large v*easure in course ol this arduous task. Onlg because of his inspiration could I confid.entlg evnbark upon a research work of such magnitude. He has helped vne itwpt'ove alr*ost everg aspect ol mg life. I feel compelled to give wanm gratitude ta Prof. Dr. Jasr^i^ Shah; r^g casupewisor who is integral to rag education in the analgtical sciences and inspirations to vng professional and personal developtnent- Her i^valver e^t with her originalitg has triggered and nourished ,Ag i^tellectual vAaturitg that I will benefit frowr, for a lowg time to cor"te. I aM trulg i^debted ta bath of thew. I ca^'t tha^k the4 e^ough,, but I prag Allah, to bless thev"t lor their efforts and rewav'd thera accordinq to His Qe^erositg.Item 30_New Solid Phase Extraction (SPE) Methods for the Preconcentration and Determination of Toxic Heavy Metals using Indigenous Biosorbents(INSTITUTE OF CHEMICAL SCIENCES, 2011) Atta ul Haq; Supervisor By: P.ol Dr. M. Rasul JanAll praites b. to ALAH ^lo^., the ,^ost co PastioMte, lre , ost b.^.ficeft a6d ev.r ^.rciful, wAo gave ^. th. pow.r to dr, th. sight to obsewe a d th. MihA to $i^k ahd judAe. Duri,4 n! res.arch vro&, tl'er. dre a ^u^b.r of people who have .o6ributed. to a gr.^t.r zxt ^t. t wa^t ta t]\a^k thet\ bg f.w words of Ackbowledgene,.t, tt\ogh ^esz an i^sufficie^t to desarib. th.ir Fist of aU it is a gr.at how a^d, pdvil?g. to r..ord ^g dtzp sasz d gra a^de to t\g laar ed sup.tyisor Prof. pr. Muharat\aA Rasul J^^, Professor, t^stitute of Ch.rnical Sci.^c.s, U^ive6,itg of p.shawar anL vice Cha^c.llor, ULive6itg of Mal^kahd. w\ose patro^izihg, thought provokiry ^ttitudz wir^ highlg sp.aializ.d guida^.e, ski .d advic., e^couraqz6e^t aAn wkda4 ^ad.e tJ^. co^ptetio^ of this work possible. His patieha. A^d, sppott k highq a.ktauned4.d.Item 26_Investigation of New Methods for the Determination of Triazine Group of Herbicides and Its Application to Samples of Environmental Importance(INSTITUTE O, 2011) Behisht Ara; Supervisor By: Prof. Dr. Jasmin ShahAll praise be to Allah the Most Gracious and the Most Merciful, for giving me the strength and ability to complete this thesis. Peace and blessing be upon Prophet Muhammad SAW., his families, his relatives and all his followers. First and foremost, I would like to express my sincere gratitude to my teacher and supervisor Prof. Dr. Jasmin Shah for her patience, motivation, enthusiasm, and immense knowledge. It has been an honor to be her student. I appreciate all her contributions of time and ideas to make my Ph.D. experience productive and stimulating. The joy and enthusiasm she has for research work was contagious and motivational for me. She has contributed immensely to my personal and professional grooming at this Institute. I am also thankful for the excellent example she has provided as a successful woman researcher and professor.Item Novel Spectrophotometric and HPLC Methods for the Determination of Dinitroaniline and Aryloxyphenoxy Groups fo Herbicides in Environmental Samples(INSTITUTE OF CHEMICAL SCIENCES, 2011) FARHAT-UN-NISA SHEHZAD; Supervisor By: Prof. Dr.Jasmin ShahAll praise for almighty Allah who enabled and encouraged me to complete this work. He has the knowledge of known and unknown, the kind and merciful and the Holy Prophet Hazrat Muhammad Peace Be upon Him who is forever a lantern of guidance and knowledge for humanity as a whole. First, I would like to express my sincere gratitude and deep appreciation to my supervisor Prof. Dr. Jasmin Shah for her encouragement, guidance and direction throughout my PhD research work and during the completion ofthis thesis. Her help smoothed my work very much and her immense patience was essential to the completionof this Project. I feel great pleasure and honor in expressing my sincere gratitude to my co-supervisor Prof .Dr. M. Rasul Jan for his valuable guidance and constant help. I will always remain grateful to him for the liberty he graciously granted meto encroach upon his precioustime. I owe my mostsincere gratitude to Razia Khan, Samina Ashfaq, Amina Asghar, Yasir Shehzad, Ayesha Ali and all of my colleagues and faculty members of College of Home Economics and ICS for their good wishesand friendly help.Item Phytochemistry and Bioactivity of Maytenus Royleanus and Ficus Faveolata(INSTITUTE OF CHEMICAL SCIENCES, 2011) Ala uddin; Supervisor By: Dr. Ghias UddinFirst, I would like to gratefully acknowledge the enthusiastic supervision of Dr. Ghias Uddin, Professor of Chemistry, Institute of Chemical Sciences. He has built a strong, resilient, lively foundation to my career as a chemist and scientist. He has demonstrated and instilled an endless work ethic and a critical eye that is never settled. Thank you for believing in my potential and for holding me up through all odds. I would like to thank my research co-supervisor Prof. Dr. Muhammad Iqbal Choudhary, ICCBS (Director), Karachi University, who accepted me into his laboratory and research group to complete a part of my project under his kind supervision. He provided me an easy access to all the available facilities at ICCBS and encouraged me for a good career in Natural Products Chemistry. Thanks from the bottom of my heart to Dr. Phillip Crews, distinguish Professor of Chemistry, University of California, Santa Cruz, USA, for providing the greatest graduate research opportunity under HEC IRSIP program, I could have ever wished for during my seven months stay. Without his guidance, my stellar laboratory skills would have never been realized. I am thankful to Prof. Dr. Imdad Ullah (Director, Institute of Chemical Sciences) for his help and providing research facilities in the Department. I ardently extend my thanks to Prof. Dr. Rafiullah Khan and Prof. Dr. Mohammad Arfan (Ex. Director) for their help and encouraging support. My honest and humble friend Mr. Ambara Khan (Taxonomist, Degree College Daggar, Buner) is gratefully acknowledged for the field assistance. Thanks to all my colleagues; Saqib Ali, Wali Ullah, Ishfaq Khan, Mamon Ur Rashid, Alam Zeb, Mohammad Alam, Anwar Saddat, Dr. Khair Zaman, Hamid Hussain, Abdul Latif, Taj Ur Rahman, Nusarat Hussain, Hamid Tanoli, Keramat Khan, Morija, Karen Tenny, Katie Watts, Eric Majia, Sami, Steven, Helena Vervoot and Wayne Inman for their cooperation and help. I am thankful to Higher Education Commission of Pakistan for their financial support throughout my research project and for selection a fellow of IRSIP program. Last but not least, my sincere thanks to my family, especially my mother, father, wife and my brothers; Noorul khan, Adnan khan, Zahoor Ud Din, Nisar Ud Din and Malik Ibad Khan for their support and encouragement.Item Structural, Bioassay And Thermal Studies Of Metal Complexes With Novel Schiff Bases(Institute Of Chemical Sciences, UOP, 2012) Muhammad Ikram; Prof. Dr. Saeed ur Rehman-Supervisor; Prof. Dr. Imdad Ullah Mohammadza-DirectorSchiff base chemistry was elaborately studied using the anionic ligands obtained by reacting, various primary aryl amines with medicinally important salicyldehyde. Different ligands, ranging from simple non rigid bidentate/tridentate anionic Schiff base ligands to sterically free twisting ligands have been prepared. All these ligands were complexed with transition metals like cobalt, nickel, copper and zinc. The coordination complexes of square planar and distorted tetrahedral geometry were obtained for bidentate anionic Schiff base ligands and octahedral for tridentate Schiff base ligands. Characterization of all the Schiff base ligands were done using various spectroscopic and analytical methods including 1H, 13C{1H}-NMR, infrared spectroscopic method, ES+-MS, elemental analyses and conductance studies. Apart from it Schiff base ligands like 2-[(E)-(quinolin-3-ylimino)methyl]phenol (H-QMP), [1-({[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]amino}methyl)cyclohexyl]acetic acid (H-HHMAC) and 2-(2-hydroxyphenyl)-3-{[(E)-(2-hydroxyphenyl)methylidene]amino}-2,3-dihydroquinazolin-4(1H)-one (H-HHAQ) were recrystallized from concentrated THF solution in Pc, P1 and C2221 space groups respectively. All the synthesized transition metal complexes of the representative Schiff base ligands were also characterized by elemental analyses, ES+-MS, IR and UV Visible spectroscopic studies, magnetic susceptibilities and molar conductance studies. The metal complexes like 1 and 2 were recrystallized by slow diffusion of diethyl ether into the concentrated solution of metal complexes in CH2Cl2 in P21/c space group having trans square planar arrangement of ligand around the metal centers.Item 16_Effects of Thyroid Profile Changes on the Biochemical Markers of Bone, Liver and Renal Function in Non-pregnant Women of Khyber Pakhtunkhwa Pakistan(INSTITUTE OF CHEMICAL SCIENCES, 2012) Mohammad Yousaf; Supervisor By: Dr. JASMIN SHAHThis hospital based cross sectional study was conducted from 01 March 2014 to 31 March 2015 in Khyber Teaching Hospital (KTH), a tertiary care hospital in Khyber Pakhtunkhawa (KP) province of Northern Pakistan. The study group comprises of 259 non pregnant women in the age group of 18-75 years. Informed consent was sought from each patient and all human dignity was respected throughout the study period in accordance with the international norms involving human as an experimental subjects. 5 mL of fresh venous blood (fasting sample) was taken from each patient. It was divided into two portions- one portion was used for the determination of thyroid profile markers by Elisa methods and the other portion was used for the determination of serum alkaline phosphatase, calcium, Zinc, urea, creatinine, SGPT and SGOT level on autoanalyser (Erbamannhein chemistry autoanalyser, Germany) by using Erba kits and Standard protocols. After the determination of thyroid profile status, patients having normal thyroid profile (n=54, TSH≤6.0, normal T3 and T4 levels) were taken as controls. While the hypothyroid patients (n=96) and hyperthyroid group (n=109) constituted the study group. The patients in the hypothyroid groups were further sub divided into Sub clinically hypothyroid (Sh) (n=48) and Overtly hypothyroid (Oh) (n=48). Similarly the patients in hyperthyroid groups were also subdivided into Overtly Hyperthyroid (OH) (n=58) and Sub clinically Hyperthyroid (SH) (n=51).Item Effect fo Enhanced Atmospheric Carbon Dioxide on the Nutritional Quality of Selected Dietary Vegetables by Andaleeb Azam(INSTITUTE OF CHEMICAL SCIENCES, 2012) Andaleeb Azam; Supervisor By: Prof. Dr. Ikhtiar KhanAll praise be to Allah the Most Gracious and the Most Merciful, for giving me the strength and ability to complete this thesis. Peace and blessing be upon Prophet Muhammad SAW., his families, his relatives and all his followers. First and foremost, I would like to express my sincere gratitude to my teacher and supervisor Prof. Dr. Ikhtiar Khan for his patience, motivation, enthusiasm, and immense knowledge. It has been an honor to be his student. I appreciate all his contributions of time and ideas to make my Ph.D. experience productive and stimulating. The joy and enthusiasm he has for research work was contagious and motivational for me. He has contributed immensely to my personal and professional grooming at this Institute. I owe my deepest gratitude to my co-supervisor Dr. Abid Mahmood for devoting his precious time, providing numerous ideas, valuable suggestions and research facilities at Barani Agriculture Research Institution, Chakwal, which indeed helped to improve quality of this research work. Without his help and guidance, this work would not have been possible. I am truly indebted and thankful to my foreign supervisor Dr. Barry Lomax, University of Nottingham, for his support and guidance during my six month research at University of Nottingham, United Kingdom.