PhD Theses and Dissertations
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Item Phytochemistry and Bioactivity of Maytenus Royleanus and Ficus Faveolata(INSTITUTE OF CHEMICAL SCIENCES, 2011) Ala uddin; Supervisor By: Dr. Ghias UddinFirst, I would like to gratefully acknowledge the enthusiastic supervision of Dr. Ghias Uddin, Professor of Chemistry, Institute of Chemical Sciences. He has built a strong, resilient, lively foundation to my career as a chemist and scientist. He has demonstrated and instilled an endless work ethic and a critical eye that is never settled. Thank you for believing in my potential and for holding me up through all odds. I would like to thank my research co-supervisor Prof. Dr. Muhammad Iqbal Choudhary, ICCBS (Director), Karachi University, who accepted me into his laboratory and research group to complete a part of my project under his kind supervision. He provided me an easy access to all the available facilities at ICCBS and encouraged me for a good career in Natural Products Chemistry. Thanks from the bottom of my heart to Dr. Phillip Crews, distinguish Professor of Chemistry, University of California, Santa Cruz, USA, for providing the greatest graduate research opportunity under HEC IRSIP program, I could have ever wished for during my seven months stay. Without his guidance, my stellar laboratory skills would have never been realized. I am thankful to Prof. Dr. Imdad Ullah (Director, Institute of Chemical Sciences) for his help and providing research facilities in the Department. I ardently extend my thanks to Prof. Dr. Rafiullah Khan and Prof. Dr. Mohammad Arfan (Ex. Director) for their help and encouraging support. My honest and humble friend Mr. Ambara Khan (Taxonomist, Degree College Daggar, Buner) is gratefully acknowledged for the field assistance. Thanks to all my colleagues; Saqib Ali, Wali Ullah, Ishfaq Khan, Mamon Ur Rashid, Alam Zeb, Mohammad Alam, Anwar Saddat, Dr. Khair Zaman, Hamid Hussain, Abdul Latif, Taj Ur Rahman, Nusarat Hussain, Hamid Tanoli, Keramat Khan, Morija, Karen Tenny, Katie Watts, Eric Majia, Sami, Steven, Helena Vervoot and Wayne Inman for their cooperation and help. I am thankful to Higher Education Commission of Pakistan for their financial support throughout my research project and for selection a fellow of IRSIP program. Last but not least, my sincere thanks to my family, especially my mother, father, wife and my brothers; Noorul khan, Adnan khan, Zahoor Ud Din, Nisar Ud Din and Malik Ibad Khan for their support and encouragement.Item Phytochemistry and Bioactivities of Selected Plants belonging to Erythrina Euphorbia and Sorbus Genera(INSTITUTE OF CIIEIIIICAL SCIENCES, 2012) Abdul Latif; Supervisor By:'Iftis is to ceftify tfrat tnlt ttssertation Itrelraretr 6y r,rr. Abtrltt LatiJ entithtr ""tytocnemistry and Bita.ti\/itizs of ktected "hnts Bebving to rrythrin4 Euf6.orbi4 antr Sorbus qerAra,' is acceptet in ttu Jrresmt form 6! ttu 'rttitute of Chemirat Sciei.es, 'lJniyersit! of "es64a/ar at fuqitt^g tnit part of ttu reErirenunts for tfu degreeItem Phytochemical Investigation and Bioactivites of Pistacia Integerrima and Diospyros Lotus(INSTITUTE OF CHEMICAL SCIENCES, 2014) Abdur Rauf; Supervior By: Prof. Dr. Ghias UddinIn the Holy name of Almighty Allah who gave me courage and strength to complete this research work. I am grateful to owe my gratitude to Almighty Allah who provided me the opportunity of exploring two natural indigenous medicinal plants at the biochemical level. I feel uncountable pleasure in heart to express my inexpressible thanks to my current ever encouraging, enthusiastic and learned supervisor, Prof. Dr. Ghias Uddin (Institute of Chemical Sciences, University of Peshawar), for his personal interest, guidance, valuable suggestions, positive criticism and discussions enabled me to complete this work. The work personified in this dissertation would have never been accomplished without Prof. Dr. Bina S. Siddiqui (Co-supervisor) for critical attention, continuous encouragement and providing access to excellent facilities at H.E.J. Research Institute of Chemistry: International Center for Chemical and Biological Sciences, University of Karachi, Karachi. I am also thankful to Prof. Dr. Mohammad Arfan for valuable ideas, discussion, preliminary attention, continuous encouragement, to pursue the research work. I would like to express my gratitude thanks to our collaborator particularly Prof. Dr. Josep Molnar and Dr. Akos Csoka (Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary) and Prof. Dr. Thomas J. Simpson (School of Chemistry, University of Bristol, Bristol, UK) for contribution and anticancer study. My humble thanks go to Prof. Dr. Yousaf Iqbal (Director, Institute of Chemical Sciences) for facilitating my research work by the proper utilization of indigenous fellowship funds. I am also thankful to all faculty members of InstituteItem Phytochemical and Biological Studies on Viburnum Grandiflorum(INSTITUTE OF CHEMICAL SCIENCES, 2014) Muhammad Alam; Supervisor By: Prof. Dr. Ghias UddinIn the name of almighty Allah, the most merciful and beneficent, who blessed me the intellectual strength to carry out this research work and to investigate the physique of the molecules existing in nature. I feel great indulgence to state my indescribable thanks to my encouraging, cooperative and learnt supervisor Prof. Dr. Ghias Uddin (Foreign Professor, Institute of Chemical Sciences, University of Peshawar) whose personal interest, proper guidance and important advices, suggestions and discussions enable me to successfully complete my research work. The research work illustrate in the current study would have never been accomplished without the crucial and continuous support of my co-supervisor Prof. Dr. Bina Shaheen Siddiqui (HEJ Research institute of Chemistry, University of Karachi) who provided me advanced research facilities available to any student of the Institute. I convey my sincere appreciation and admiration to Prof. Dr. Yousaf Iqbal (Director Institute of Chemical Sciences, University of Peshawar) who facilitate my research work and thanks to all the faculty members particularly to all professors of organic chemistry for their ethical support.Item Phytochemical and Biological Investigation on Paeonia Emodi Wall Ex Royl and Bergenia Ligulata Sensu Blatter(INSTITUTE OF CHEMICAL SCIENCES, 2014) Anwar Sadat; Supervisor By : Prof. Dr. Ghias UddinIn the name of Allah who is the Creator of the Universe who gave me puissance to consummate this research work and to explore the physique of the molecules originating in nature. I feel great elatedness to express my indefinable appreciativeness thanks to my encouraging, animate and learnt supervisor Prof. Dr. Ghias Uddin (Foreign Professor, Institute of Chemical Sciences, University of Peshawar) whose personal interest, guidance and consequential advices, suggestions and discussions enfranchised me to complete my research work. The research work illustrated in the current dissertation would have nerve been accomplished without the momentous and endless encouragement of my co-supervisor Prof. Dr. Bina Shaheen Siddiqui (HEJ Research institute of Chemistry, University of Karachi) who provided me with advanced research facilities available to any student of the institute. I convey my deepest gratitude and appreciation to Prof. Dr. Yousaf Iqbal (Director Institute of Chemical Sciences, University of Peshawar) who guided me during the course of my Ph.D. in the right direction and facilitated my research work and thanks to all the faculty members particularly to all professors of organic chemistry for their moral support. I am highly thankful to Higher Education Commission of Pakistan for financial support under the indigenous fellowship scheme and access to modern spectroscopic and biological assay techniques.Item Phytochemical and Biological Investigation on Berberis Jaeschkeana Schneid Var, Jaeschkeana and Berberis Glaucocarpa Stapf(INSTITUTE OF CHEMICAL SCIENCES, 2013) Muhammad Alamzeb; Supervisor By: Dr. M. Rafiullah KhanFirst of all I would like to thank Allah who blessed me with good health and intellect to carry out and complete this work. It is all because of his blessings that I have reached this level of knowledge in the field of chemistry. I am truly indebted to my parents and family members whose prayers and support have enabled me to complete this stupendous work. I am very greatful to my affectionate and cooperative supervisor, Prof Dr. M. Rafiullah Khan for his sincere cooperation and guidance. I would also like to thank my supervisors Dr. Valerie. A. Ferro and Prof Dr. Alexander Irvine Gray (SIPBS, University of Strathclyde, Glasgow UK.) for their guidance and help especially in the interpretation of 1D and 2D NMR spectra, I am also thankful to Dr. John Igoli, University of Strathclyde, Glasgow UK for his help and cooperation. I am thankful to Prof Dr. Yousaf Iqbal (Director ICS) and other staff and academic members of ICS for their support and cooperation. I am also greatful to the Higher Education Commission of Pakistan for funding and supporting my research work both in Pakistan and UK. My special gratitude and thanks to Prof Dr. Tanveer Akhtar (Chairperson Botany Department University of Azad Jammu and Kashmir) for the identification of my plant species on such a short notice.Item Phytochemical and Biological Investigation on Artemisa Elegantissima Pamp and Artemisa Incisa Pamp (Asteraceae)(INSTITUTE OF CHEMICAL SCIENCES, 2014) Mamoon ur Rashid; Supervisor By: Dr. M. Rafiullah KhanIn the name of Allah, the Most Beneficent and the Most Merciful, Alhamdulillah; all praises to Allah (the Almighty) for blessing me strength and mental power to complete this dissertation. It is only His benedictions which enabled me to study chemistry at its apex level of knowledge. I desire to acknowledge a number of people who influenced and supported me directly or indirectly in finalizing this dissertation. A deep sense of gratefulness and obligation is extended to my supervisor, Prof. Dr. Muhammad Rafiullah Khan, for his supervision and constant support. His invaluable help of constructive comments and suggestions throughout the research and thesis works have contributed to the success of the project. I am pleased to acknowledge my foreign supervisors Prof. Dr. Alexander I. Gray and Dr. Valerie A. Ferro, University of Strathclyde, Glasgow, UK. Without the caring instructions and guidance of them, I would not be able to complete my research work with in time.Item Phytochemical and Biological Investigation of Some Species of Family Leguminosae(INSTITUTE OF CHEMICAL SCIENCES, 2009) Khair Zaman; Supervisor By: Dr. M. Rafiullah KhanAt the very outset of my acknowledgementI would like to thankAllah for blessing me with good health and intellect to accomplish this work. It is only His blessings which enabled me to reachthis apex level of knowledge in the field of Chemistry. This workis a synergistic product of many minds. I am grateful for the inspiration, knowledge and wisdom of all the thinkers who enabled me to put pen to paper, among them are my parents, all myrespectedteachers, students and friends who deserve first mention in this dissertation. A deepsense of gratitude andindebtedness is extendedto ever alfectionate Prof. Dr. M. Rafiullah Khan for his sincere cooperation and encouragement. Many people and forces contrihuted significantly to the completion of this study. They all deserve my deepest gratitude for providing me the opportunity and conditions to complete this thesis. | wish to thank a numberof people who influenced and supported me directly or indirectly in completing this dissertation. Perhaps words are too shallow to express mygratitude to mysupervisor Prof, Dr. Rafiullah Khan. Without his academic guidance, enthusiastic support, scholarly advice and critical feedback, it would not have been possible for me to accomplish this scholastic task. | must pay him a warmtribute for his kind behaviour, valuable advice, constructive criticism, timely suggestions, hourlong discussions and constant encouragement all the time.Item Phytochemical and Bioactivity of Selected High Altitude Plants belonging to Ligularia, Senecio and Vernonia Genera(INSTITUTE OF CHEMICAL SCIENCES, 2012) Syed Hamid Hussain; Supervisor By: Prof. Dr. Ghias UddinWords are bound and knowledge is limited to praise Allah, the most Beneficent, the Merciful, Gracious and the Compassionate whose bounteous blessing and exaltation flourished my thoughts and thrived my ambition to have the cherish fruit of my modest efforts in the form of this dissertation from the blooming spring of blossoming knowledge. My special praise for the Holy Prophet Hazrat Muhammad (Peace Be Upon Him), the greatest educator, the everlasting source of guidance and knowledge for humanity. He taught the principles of morality and eternal values. I deem it a great honor to express my deepest sense of gratitude to my honorable and estimable supervisor Prof. Dr. Ghias Uddin (Foreign Professor, Institute of Chemical Sciences, University of Peshawar), for his kind and able guidance, valuable comments, inspiring and encouraging attitude throughout the course of my studies. I do not find appropriate words to express my deep sense of obligation to my Ex-research supervisor, Prof. Dr. Mohammad Arfan, for their valuable guidance, sympathetic behavior and persistent encouragement. Not forgotten, my appreciation to my co-supervisor, Prof. Dr. Farzana Shaheen (HEJ Research Institute of Chemistry, University of Karachi) for providing me access to all the available facilities in the institute. I would like to express my deepest sincere gratitude to Prof. Thomas J. Simpson, Prof. Russell J. Cox and Dr. Craig Butts (School of Chemistry, University of Bristol, UK) for giving me a unique opportunity to work in their laboratories. Their continuous guidance, invaluable suggestions, affectionate encouragement, generous help and important acumen are greatly acknowledged. I feel great pleasure in expressing my sincerest thanks to Prof. Dr. Imdadullah (Director, Institute of Chemical sciences, University of Peshawar) for providing necessary infrastructure and resources to accomplish my research work. I take this opportunity to sincerely acknowledge the Higher Education Commission (HEC) of Pakistan, for financial support under indigenous fellowship program and also for my research visit to the University of Bristol, UK, under the commendable scheme (International Research Support Initiative Program).Item Novel Spectrophotometric and HPLC Methods for the Determination of Dinitroaniline and Aryloxyphenoxy Groups fo Herbicides in Environmental Samples(INSTITUTE OF CHEMICAL SCIENCES, 2011) FARHAT-UN-NISA SHEHZAD; Supervisor By: Prof. Dr.Jasmin ShahAll praise for almighty Allah who enabled and encouraged me to complete this work. He has the knowledge of known and unknown, the kind and merciful and the Holy Prophet Hazrat Muhammad Peace Be upon Him who is forever a lantern of guidance and knowledge for humanity as a whole. First, I would like to express my sincere gratitude and deep appreciation to my supervisor Prof. Dr. Jasmin Shah for her encouragement, guidance and direction throughout my PhD research work and during the completion ofthis thesis. Her help smoothed my work very much and her immense patience was essential to the completionof this Project. I feel great pleasure and honor in expressing my sincere gratitude to my co-supervisor Prof .Dr. M. Rasul Jan for his valuable guidance and constant help. I will always remain grateful to him for the liberty he graciously granted meto encroach upon his precioustime. I owe my mostsincere gratitude to Razia Khan, Samina Ashfaq, Amina Asghar, Yasir Shehzad, Ayesha Ali and all of my colleagues and faculty members of College of Home Economics and ICS for their good wishesand friendly help.Item 30_New Solid Phase Extraction (SPE) Methods for the Preconcentration and Determination of Toxic Heavy Metals using Indigenous Biosorbents(INSTITUTE OF CHEMICAL SCIENCES, 2011) Atta ul Haq; Supervisor By: P.ol Dr. M. Rasul JanAll praites b. to ALAH ^lo^., the ,^ost co PastioMte, lre , ost b.^.ficeft a6d ev.r ^.rciful, wAo gave ^. th. pow.r to dr, th. sight to obsewe a d th. MihA to $i^k ahd judAe. Duri,4 n! res.arch vro&, tl'er. dre a ^u^b.r of people who have .o6ributed. to a gr.^t.r zxt ^t. t wa^t ta t]\a^k thet\ bg f.w words of Ackbowledgene,.t, tt\ogh ^esz an i^sufficie^t to desarib. th.ir Fist of aU it is a gr.at how a^d, pdvil?g. to r..ord ^g dtzp sasz d gra a^de to t\g laar ed sup.tyisor Prof. pr. Muharat\aA Rasul J^^, Professor, t^stitute of Ch.rnical Sci.^c.s, U^ive6,itg of p.shawar anL vice Cha^c.llor, ULive6itg of Mal^kahd. w\ose patro^izihg, thought provokiry ^ttitudz wir^ highlg sp.aializ.d guida^.e, ski .d advic., e^couraqz6e^t aAn wkda4 ^ad.e tJ^. co^ptetio^ of this work possible. His patieha. A^d, sppott k highq a.ktauned4.d.Item 29_Method Development and Validation for Antipsychotic Drugs Application to Pharmaceutical Preparations and Biological Samples(INSTITUTE OF CHEMICAL SCIENCES, 2013) Muhammad Naeem Khan; Supervisor By: Prof. Dr. Muhammad Rasul JanAll praise to Allah the Omniscient, who thought man what, he not knew, who equipped his humble creature with mental facility, which enabled and encouraged me to complete this work. Peace and blessing be upon Prophet Muhammad SAW., his families, his relatives and all his followers. A single flower cannot make a garden or a single star cannot make the beautiful shiny sky. The same way a research work can never be the outcome of a single individual‘s talent or effort. During my trip from objective to goal, I have experienced shower of blessings, guidance and inspiration from my teacher’s parents and all my well wishers. Though it is not possible for me to name and thanks them all individually, but it is great pleasure for me to pen down some of the distinct personalities who have made it possible for me to put this research work in present form.Item Malondialdehyde A Marker of Oxidative Stress in Diabetes Mellitus With and Without Coronary Heart Disease(INSTITUTE OF CHEMICAL SCIENCES,, 2006) Muhammad Ahmad; Supervisor By: Dr. abdus Sattar KhanWith g@r pl.durc I dp6s my gtldrudc to Dr. A- S.d'r Khaq M.S.. Ph.D., PFfc$. of BimrEnist y, Koh.t Univdity of S.i.M sd Tdhnolo&', Koha! stlo prcvid.d srcat inantirc, crcomg.ncnt and guidmc. I m ako g6r.irl to Dr, HaMn u R4hid, M.sc. Ph,D,, ?rcf.st ed Ch!iE!4 D.parthcnt ofchmkry. Unjvdity oft.shlwr, for hi! h.tp old cuid&c. thdu8hour ihis Es.arh, I u dso g6Gtul ro Dr. Mudrsir AlDrd ru.4 M.B.B_S., M.phil.. !h.D., tueciarc Prof€sr Dcpgrr!.nr of Bi@h.nist y, Khybcr Medical Collcgd, tahw, who id spir. of bcitrs vdy buy s g@ioB GnouSh &. his gujd@, 4@ugdat dd uEDn hclp dwirS wiou .r!g6 of lhc $carch poj.ct,nd the dcElopmqr ofilis th6is, M6y rhd.b ro Dr. ZlrtuNl.h, rnch&g., !MRC, Rcsadh ccdr.., Kihybd Medi@l Coltcge, p.shawr. for prcvidins n @sery Ebonrory fa.ilitiB 0F!g[our Ojs Esrcl pDje1Item 27_Lipid Metabolism Study in Women of Pregnancy Induced Hypertension Cases(INSTITUTE OF CHEMICAL SCIENCES, 2010) Rubina Nazli; Supervisor By: Prof. Dr Muhammad Rasul JanAll acclamations and appreciation’s are for all mighty Allah, who bestowed mankind with knowledge and wisdom. Allah has the knowledge of known and unknown and equipped his humble creature with mental facility to search for his creation. This is his mercy and grace that enabled me to complete this work. I feel great pleasure and honor in expressing my sincere gratitude to my supervisor, Prof. Muhammad Rasul Jan, Ex Director, Institute of Chemical Sciences University of Peshawar and present Vice Chancellor of Malakand University, for his valuable guidance, constant help and encouragement throughout this work. I want to thanks Prof. Dr.Jasmin shah, Institute of Chemical Sciences University of Peshawar for her kind behavior, valuable advices, timely suggestions and constant encouragements all time.Item 26_Investigation of New Methods for the Determination of Triazine Group of Herbicides and Its Application to Samples of Environmental Importance(INSTITUTE O, 2011) Behisht Ara; Supervisor By: Prof. Dr. Jasmin ShahAll praise be to Allah the Most Gracious and the Most Merciful, for giving me the strength and ability to complete this thesis. Peace and blessing be upon Prophet Muhammad SAW., his families, his relatives and all his followers. First and foremost, I would like to express my sincere gratitude to my teacher and supervisor Prof. Dr. Jasmin Shah for her patience, motivation, enthusiasm, and immense knowledge. It has been an honor to be her student. I appreciate all her contributions of time and ideas to make my Ph.D. experience productive and stimulating. The joy and enthusiasm she has for research work was contagious and motivational for me. She has contributed immensely to my personal and professional grooming at this Institute. I am also thankful for the excellent example she has provided as a successful woman researcher and professor.Item 25_Influence of Some Heterogeneous Catalyst on Pyrolytic Conversion of Model Polyropylene and High Density Polyethylene into Fuel like Products(INSTITUTE OF CHEMICAL SCIENCES, 2014) Mohammad Ismail Khan; Supervisor By: Prof. Dr.Imtiaz AhmadI wish to thank and acknowledge the following: Almighty Allah for all his blessings and for everything bestowed upon me. My worthy supervisor, Prof. Dr.Imtiaz Ahmad and co-supervisor, Prof.Dr.Hizbullah Khan for their guidance, helpful attitude, timely suggestions and patience throughout the course of this study. Director, Institute of Chemical Sciences for providing the research facilities. My worthy teachers, Prof. Dr.M. Arsala Khan, Prof. Dr. M. Shakirullah (Late), and Prof, Dr. M. Ishaq for their constant support and encouragements. Dr. Kashif Gul and Dr.Waqas Ahmad for their unflagging faith and encouragements throughout the course of this work. Higher Education Commission, Islamabad for financial support through Access to Scientific Instruments programm. Laboratory and Ministerial staff of the Institute of Chemical Sciences, University of Peshawar for their untidy support and help in taking care of codal formalities related to my work. All family members particularly my wife and kids for their sacrifices, love and constant prayers and encouragements. All friends for their support and inspirations in difficult movements. All those who directly and indirectly helped me.Item 24_Influence of Crude Methanolic Extracts of Rice-Husk and Saw-Dust as Antioxidants on Thermo-Oxidative Stability of Base Lubricating Oil(INSTITUTE OF CHEMICAL SCIENCES, 2015) Jan Ullah; Supervisor By: Prof. Dr.Imtiaz AhmadI, the undersigned wishes to acknowledge the all mighty ALLAH and the listed individuals & institutions: My worthy supervisor, Prof. Dr.Imtiaz Ahmad for his friendly attitude, guidance, help, valuable suggestions and encouragements during the course of this study Prof. Dr.Yousaf Iqbal, Director, Institute of Chemical Sciences My worthy teachers, namely Prof. Dr. M. Ishaq, Dr. M. Yaseen, Dr. Waqas Ahmad and Dr. Kashif Gul for their support Quarter concerned of the Higher Education Commission, Islamabad for Access to Scientific Instruments Laboratory staff , Institute of Chemical Sciences, University of Peshawar Ministerial staff, Institute of Chemical Sciences, University of Peshawar Directorate of Admissions, University of Peshawar Parents, wife, children and all family members Friends, laboratory colleagues, and class fellows All those who directly and indirectly helped me in successful completion of this thesis.Item Functionalization and Heteroannulation of Quinazolone Nucleus-Synthesis, Structure Elucidation and Bioactivity Evaluation(INSTITUTE OF CHEMICAL SCIENCES, 2008) RASOOL KHAN; Supervisor By: Dr. Mohammad ArfanThe research work documented in this dissertation presents the synthesis and bioactivity evaluation of some quinazolin-4(3.H)-one based heterocyclic compounds. Part first is concerned with the synthesis and synthetic methods both reported and newly designed and developed, while the second part is about the bioassays evaluation of the synthesized quinazolin-4(3H)-ones. 2-Aryl -4H-3,1-benzoxazin-4-one and methyl-Nacylanthranilates were prepared as starting materials for further transformations into a series of various 2,3-disubstituted quinazolin-4(3H)-ones. Keeping in view the extensive applications of 2-aryl -4H-3,1-benzoxazin-4-one as precursor in the quinazolin-4(3H)-ones chemistry, a new, cheaper andfacile one-pot method for the synthesis of 2-aryl -4H-3,1-benzoxazin-4-one was developed making use of readily available substituted benzoic acids. A faster and high- yielding microwaveassisted, solvent free method was also developed for the synthesis of methyl-2- [(trifluoroacetyl) amino] benzoate. Both the 2-aryl -4H-3,1-benzoxazin-4-one and methyl-N-acylanthranilates synthesized were then utilized for the synthesis of 3-amino, 2-alkyl/aryl quinazolin- 4(3H)-ones and 2,3-disubstituted quinazolin-4(3H)-ones. Consequently, a series of fifteen (19-33) 3-amino- 2-alkyl/aryl substituted quinazolin-4(3H)-ones anda series of twenty seven (46-62) 2,3-disubstituted quinazolin-4(3 H)-ones were synthesized. The necessity of development of new, cheaper and faster methods was realised and as a result, a simpler and less tedious three component one-pot method for the synthesis of ten ( 22-31) 3-amino, 2-aryl quinazolin-4(3H)-ones was developed starting from the available substituted benzoic acid. As a consequenceof the effect of substituents on the reactivity of 2-aryl -4H-3,1- benzoxazin-4-ones, three structurally novel quinazolin-4(3H)-ones (34-36) were synthesized from substituted 2-phenyl-4H-3,1-benzoxazin-4-ones. It was found that phenyl group substituted at position 2 failed to give any product. Reasons for the observed effect onthe reactivity are proposed. Keepingin view the importance of the nature and position of substituents in drug discovery, a series of (37-62) 2, 3-disubstituted quinazolin-4(3H)-ones were synthesized employing three different methods. The effect of substituents on the reactivity and theItem Extraction of Toxic Metal Ions by Using Different Carriers through Flat-Sheet Supported Liquid Membrane Technique(INSTITUTE OF CHEMICAL SCIENCES, 2016) Robila Nawaz; Supervisor By: Dr. Khurshid AliAll praises for Almighty Allah, Who gave me the strength and courage to complete this work. Tremendous respect is for Holy Prophet (Peace Be Upon Him). I wish to express my sincere gratitude, heartiest obligation and appreciation to my worthy, learned, hardworking and experienced supervisor, Dr. Khurshid Ali, Professor, Institute of Chemical Sciences, University of Peshawar for his guidance and helping attitude throughout my research work. I would like to express my appreciation to Prof. Dr. Yousaf Iqbal, Director Institute of Chemical Sciences, University of Peshawar, for his encouraging attitude and providing all research facilities for this work. I gratefully acknowledge the Higher Education Commission of Pakistan for financial support and providing me opportunity to complete my research work at the Institute of Chemical Sciences, University of Peshawar through Indigenous Ph.D. Fellowship Program. I would like to thanks my respected professors of the Institute of Chemical Sciences who helped me in various ways during this research work. I express my special thanks to Dr. Anwar ul Haq for providing cooperative, enthusiastic and intellectual atmosphere.Item Extraction of Metal Ions by Coupled Transport Mechanism using Supported Liquid Membranes(INSTITUTE OF CHEMICAL SCIENCES, 2012) Gul Akhtar; Supervisor By: Prof. Dr. Saeed ur RehmanFirst and foremost, all the gratitude be to Almighty Allah, the most powerful and merciful, who blessed me with the stamina to accomplish this project. I am really thankful, from the core of my heart, to my learned co-supervisor, Dr. M. Ashraf Chaudry, for his deep interest in research work, useful suggestions, technical guidance and sincere encouragement. I would like to express thanks to my supervisor, Dr. Saeed ur Rehman, meritorious Professor, for his kind supervision, guidance, valuable advices and inspiring attitude enabling me to complete this work. Special thanks are due to Dr. Khurshid Ali and Dr. Imtiaz Ahmed for their guidance during thesis write-up. Thanks are also due to Dr. Naheed Bukhari for her cooperation in research work. I would like to express my appreciation to Prof. Dr. Imdad Ullah Mohammadzai, Director Institute of Chemical Sciences University of Peshawar, for his encouraging attitude and providing all research facilities in the Institute. I gratefully acknowledge all my respected teachers in the Institute of Chemical Sciences for their valuable guidance during the research studies. Thanks are also due to all my lab fellows and colleagues for their moral and technical support.