PHYTOCHEMICAL, PHARMACOGNOSTIC AND PHARMACOLOGICAL INVESTIGATIONS OF VITEX AGNUS CASTUS AND MYRSINE AFRICANA
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Date
2001
Journal Title
Journal ISSN
Volume Title
Publisher
Center of Biotechnology
Abstract
The present Ph.D dissertation comprises of two parts, part A and part B.
The part A describes extraction, isolation and structure elucidation of isolated
compounds. Pharmacological and biological activities of crude extract, different
fractions thereof and some compounds isolated in reasonable quantity from Vitex agnus
castus have been investigated.
As regarded phytochemical study three new compounds namely vitexcarpan (01)
vitexcarpan 1 (02) and Vitexoide (03) were isolated from the aerial parts of the plant in
amount of 10.0, 16.4 and 5.0 mg respectively. Other known compounds (04, 05 and
06) were also isolated from this plant along with.
Crude methanol extract, different fractions thereof and some compounds isolated in fair
quantity were investigated for various pharmacological / biological activities including,
Antibacterial, Antifungal, Brine-shrimp lethality, Phytotoxic, Heamagglutination,
Insecticidal, Anti-termites, Anti-inflammatory, Spasmolytic, Nitric oxide free radical
scavenging assay and Enzyme inhibition assay.
The Pharmacological / Biological investigations revealed that the plant possess significant
Antibacterial, Anti-inflammatory and Spasmolytic activity. The plant materials showed
Good Phytotoxicity (at higher concentrations), Anti-termites and Nitric oxide free radical
scavenging activities. Moderate insecticidal and Brine shrimp lethality were also
observed. The plant was also found to exhibit no Antifungal and Heamagglutination
activity. Moderate and low Enzyme inhibition and Anti-inflammatory activities were
observed for the isolated compounds.