16_Effects of Thyroid Profile Changes on the Biochemical Markers of Bone, Liver and Renal Function in Non-pregnant Women of Khyber Pakhtunkhwa Pakistan
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Date
2012
Journal Title
Journal ISSN
Volume Title
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INSTITUTE OF CHEMICAL SCIENCES
Abstract
This hospital based cross sectional study was conducted from 01 March 2014 to 31 March 2015 in Khyber Teaching Hospital (KTH), a tertiary care hospital in Khyber Pakhtunkhawa (KP) province of Northern Pakistan. The study group comprises of 259 non pregnant women in the age group of 18-75 years. Informed consent was sought from each patient and all human dignity was respected throughout the study period in accordance with the international norms involving human as an experimental subjects. 5 mL of fresh venous blood (fasting sample) was taken from each patient. It was divided into two portions- one portion was used for the determination of thyroid profile markers by Elisa methods and the other portion was used for the determination of serum alkaline phosphatase, calcium, Zinc, urea, creatinine, SGPT and SGOT level on autoanalyser (Erbamannhein chemistry autoanalyser, Germany) by using Erba kits and Standard protocols.
After the determination of thyroid profile status, patients having normal thyroid profile (n=54, TSH≤6.0, normal T3 and T4 levels) were taken as controls. While the hypothyroid patients (n=96) and hyperthyroid group (n=109) constituted the study group. The patients in the hypothyroid groups were further sub divided into Sub clinically hypothyroid (Sh) (n=48) and Overtly hypothyroid (Oh) (n=48). Similarly the patients in hyperthyroid groups were also subdivided into Overtly Hyperthyroid (OH) (n=58) and Sub clinically Hyperthyroid (SH) (n=51).